A 7.1-magnitude quake 124 kilometers southwest of the town of Puquio off the coast of Peru, according to the U.S. Geological Survey (USGS).
The large quake occurred about 25 miles offshore from Acari, a town in Peru's southern Arequipa region, the U.S. Geological Survey reported.
Arequipa Gov. Yamila Osorio said on Twitter that one 55-year old man died in the town of Yauca after being crushed by rock. Jorge Chavez, chief of Peru's Civil Defense Institute, told local radio station RPP that 65 people were injured.
Electricity was out in several municipalities and many roads were closed or passable in only one direction, the mayor said.
Residents of Lomas were evacuated after feeling an aftershock, she said. Speaking to reporters, he attributed the two deaths to adobe houses collapsing.
Many homes in the city were built on risky inclines with cheap construction materials and are not up to construction code, experts have warned.
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The last major natural disaster to shake Peru hit in August 2007, killing 595 people.
"The victim reportedly found in Bella Union has not been confirmed", Chavez said.
There were no initial reports of damage and no tsunami warning was issued by Peruvian authorities..
A USA agency says there is no longer a tsunami threat from a powerful quake that struck off Peru.
Though it damaged roads in the region, ports and airports continue to operate normally, reported Andina, the state-run news agency.
Jesus Revilla, a union leader at the Cerro Verde copper mine in Arequipa, said there were no reports that operations had been affected.