The Dow Jones industrial average dropped 354 points, with Exxon Mobil sliding 5.7 percent. Crude oil prices rose. "I think the market is now thinking of the possibility that the Fed could raise rates four times this year rather than three".
Losses in health care stocks were offset by gains in technology companies and other sectors.
UPS was down 6.9 percent after it reported fourth-quarter profit that was hurt by higher holiday season shipping costs.
The S&P 500 is up 150.20 points, or 5.6 percent.
The Nasdaq fell 144 points, or 2 percent, to 7,240.
The Standard & Poor's 500 index gave up 30 points, or 1.1 percent, to 2,791.
Other notable index closes included the S&P 400 Mid-Cap Index at 1,953.97 for a loss of -3.49 points or -0.18%; the S&P 100 Index at 1,251.42 for a loss of -0.51 points or -0.04%; the Russell 3000 Index at 1,664.68 for a loss of -0.07 points or -0.01%; the Russell 1000 Index at 1,561.66 for a gain of 0.55 points or 0.04%; and the Dow Jones U.S. Select Dividend Index at 720.06 for a loss of -0.23 points or -0.03%.
The Nasdaq composite lost 25.62 points, or 0.3 per cent, to 7,385.86. The stock, which has been the biggest gainer in the Dow over the past year, added $17.26 to $354.97.
Google's parent company Alphabet slumped 4.6 percent Friday after reporting results that missed analysts' forecasts.
Inicia la Serie del Caribe de Guadalajara
Néstor Molina, refuerzo proveniente de Cardenales, sí le tiene tomada la medida a su adversario. Recordemos que el año pasado fueron eliminados por el equipo de México .
The Dow Jones Industrial Average is one of several indices created by Wall Street Journal editor and Dow Jones & Company co-founder Charles Dow. The stock slid $1.54 to $58.64.
OIL: Benchmark U.S. crude rose 55 cents to $65.28 per barrel on the New York Mercantile Exchange. Brent crude, used to price worldwide oils, gained 22 cents to $68.74 in London.
That caused the 10-year Treasury yield to surge to 2.8450 percent the highest since January 2014, which could make returns on Treasuries look more attractive relative to stocks.
BOND YIELDS: Bond prices fell. Boeing's move comes after the aerospace manufacturer reported better-than-expected quarterly results and provided an upbeat outlook for 2018.by virtue of its share price has been the most influential among the Dow's components in recent months. This week yields have hovered at the highest level since April 2014.
Most benchmark USA indices ended down Thursday as investors exercised caution due to fears of inflation gathering pace and rising bond yields.
CURRENCIES: The dollar rose to 108.94 yen from 108.78 yen on Tuesday.
MARKETS OVERSEAS: Germany's DAX was flat, while France's CAC 40 gained 0.2 percent.
Elsewhere, the Stoxx Europe 600 swung between small gains and losses and closed down 0.2% following its biggest daily fall of the year. In Greater China, the Hang Seng Index was up 0.14%, while on the mainland, the Shanghai Composite Index rose 0.13%. Over in Sydney, the S&P/ASX 200 gained 0.71%.