Real Madrid go into their match at home to Getafe without Marcelo, Tony Kroos and Luka Modric and with one eye on their Champions League trip to Paris the following week, where they will defend a 3-1 first leg lead.
Sevilla imploded with Koke making it 4-0 after more suicidal defending before Griezmann completed his hat-trick on 80 minutes, taking his Liga tally to 11 for the season.
Barcelona will host Atletico Madrid on Sunday, in a clash of first against second with extra weight, now that the Catalans' lead has been cut to just five points.
Jonathan Calleri scored from the spot to earn his side a vital 1-1 draw in their fight against relegation.
Although Barca's club-record unbeaten league run is extended to 33 games, the draw takes them five points above Atletico Madrid who they play next this weekend.
Barcelona will feel hard done by given Digne's handball looked entirely accidental, with Gerard Pique on the pitch after the final whistle venting his anger at the officials.
Syria ceasefire not to affect offensive in Afrin: Turkey
PKK , listed as a terrorist group by the United States and the European Union, has waged a bloody insurgency in Turkey since 1984. Turkish security officials and the Ministry of Justice have begun the administrative process for the extradition of Salih Muslim.
"We felt that they equalised with an "invisible" penalty, they grew stronger after that and we played in too much of a hurry", the agitated Valverde said.
"Nobody knows in the dressing room". I have to be ambitious and I think we can do more with the ball. "From the field I found it unspeakable, but these are things that happen".
Their last league loss was at Espanyol a year ago.
Ernesto Valverde's side were made to battle for their point in an industrious encounter, as Lionel Messi grabbed his first-ever away goal on the island in what turned out to be a frustrating night for the visitors.
The keeper was to offer less resistance next time around, however, as Messi curled an unerring set piece into the far corner to make it 1-0, after Joaquin Navarro had initially brought the playmaker down on the edge of the box.
There was plenty of confusion at the decision to award the penalty to Las Palmas, and Valverde termed the penalty an "invisible" one. The rebound then hit Lucas Digne on the arm, which the referee deemed worthy of a penalty.