United will have to forget about their clash with Liverpool and subsequent Champions league second leg as a loss to The Eagles would keep them in third place.
Palace, on the other hand, have come a long way since the last time these two sides met.
The hosts are winless in their last three games and they will be determined to move out of the relegation places. Manchester United loanee Timothy Fosu-Mensah is ineligible for this game due to the fact that he can't play against his parent club.
Crystal Palace haven't won any of their 17 PL meetings with Manchester United-the most a team has played another without a single victory in the competition (D3 L14). Another player who could be out the door come summertime is Marouane Fellaini. The one at Fulham was more dramatic because it went to the last day.
That's the view of former Blackburn striker Chris Sutton. With Townsend's pace and Benteke's strength and physicality, they have what it takes to cause a few problems to the United defence.
But Mourinho made substitutions that changed the game.
China no se quedará de brazos cruzados ante amenaza comercial de EU
Las fuerzas armadas "resguardarán con firmeza y decisión nuestra soberanía nacional, seguridad e intereses de desarrollo", dijo Li.
Jose Mourinho hits out at media criticism: "We have very good matches and we have very good periods of matches".
Additionally, Romelu Lukaku is in great form right now.
United haven't lost three consecutive Premier League away games since January 1996.
If United are to enjoy a trophy-filled climax, Lindelof could find himself unexpectedly cast as a key figure in Jose Mourinho's plans - something that looked unthinkable in his early months in Manchester.
Irwin was part of Manchester United's 1999 treble winning team the beat Bayern Munich in the Champions League final at the Nou Camp.
Can Lukaku use the Chelsea game as a springboard?
With Paul Pogba and Alexis Sanchez particularly profligate, United was terrible in the first half and conceded the opening goal when Andros Townsend's shot from the edge of the area span into the top corner off the back of United defender Victor Lindelof in the 11th.
Palace are the quintessential rabbit caught in the headlights side this season.