On Tuesday Pep Guardiola's men were sent out of the Champions League a the hands of Liverpool, three days after they were defeated in the Manchester derby. Winning titles in every league is important, with Barcelona was special.
Guardiola is concerned about the psychological effect that three defeats in a week might have on his players as they look to secure the trophy.
If Spurs were to add a fourth reversal to that run, then they would restore a 10-point advantage over Chelsea in the battle for top-four finishes.
A tumultuous return from the global break for Manchester City has come to an end.
There are two games on Saturday evening.
Israel probes video appearing to show sniper shooting Palestinian
Palestinians and rights groups accuse Israel of killing Palestinians at the border when they did not pose an immediate threat. Calls for an independent investigation into the massacre were blocked by the U.S. veto in the UN Security Council.
However, City can wrap up the title this weekend if they beat Spurs and Manchester United lose at home to bottom-side West Brom on Sunday.
But - for all their possession - they could not muster any chances and it was City that had a golden opportunity to put the game to bed in the 64th minute.
After nearly going the whole season without defeat, bar the one game against Liverpool, Man City have now lost three in a row. He has created the highest number of chances during that spell. An exciting finale to the 2017/18 Premier League season beckons... It makes for an intriguing encounter that is sure to feature some enthralling attacking football from two of the best managers in the Premier League.
Sergio Aguero was pushed through the pain barrier in midweek against Liverpool, but that was with a Champions League semi-final place on the line.
League leaders Manchester City travel to Tottenham Hotspur to get their momentum back on track after suffering three defeats on the trot. You cannot underestimate clubs like Chelsea, Arsenal, different clubs, big clubs that can win every game. The other top-six sides really go at it, both teams want to win and there is a lot more space on the pitch. They've had their own mini-drama going on this week, after the usually highly likeable Harry Kane was controversially awarded - after making an unexpectedly desperate-sounding appeal - what appeared to many to be a Christian Eriksen goal.