Israel is celebrating 70 years since the modern Jewish state was established. Israel has carried out numerous airstrikes in Syria, most believed to have targeted suspected arms shipments bound for Hezbollah.
On Wednesday, Iranian Supreme Leader Ali Khamenei called for "offensive plans against the enemy", without specifically naming Israel.
It was shot down by an Israeli helicopter, and Israel in retaliation attacked what it said were the drone's Iranian control systems in Syria.
Israelis have come to a two-minute standstill to remember fallen soldiers and victims of terrorism as the country marks Memorial Day, one of the most somber days on its calendar.
He says Israel is the closest ally of the USA, and he is looking forward to moving the US embassy to Jerusalem next month.
As Israel turns 70, people gather in the streets and beaches to take part in the Independence Day festivities across the country.
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Trump's message the night before - including that the US stands ready to respond as needed to any further chemical weapons use by Assad's regime.
Trump tweeted Wednesday that "We have no better friends anywhere".
They are likely to escalate around May 14, when the United States is expected to move its embassy in Israel from Tel Aviv to Jerusalem.
Motorists pulled over on the sides of highways and roads, and pedestrians stopped in their tracks silently with heads bowed as a siren rang out at 11 a.m.
Earlier, at a remembrance day ceremony, Netanyahu spoke of the "barbaric zealotry of radical Islam" and reiterated warnings about Iran and its presence in neighboring Syria.
Israel said on Wednesday it had found explosives hidden in a Palestinian truck that were due to be smuggled from the occupied West Bank and used in an attack on the Jewish state's Independence Day.