The film was reportedly made on a $75 million production budget. The Marvel tentpole - starring Chadwick Boseman and directed by Ryan Coogler - crossed $700 million at the domestic box office, one of three films to hit that mark.
"We believe this is a solid start for this film", Cathleen Taff, Disney's head of theatrical distribution, said.
"Christopher Robin", $25 million ($4.8 million international).
Fallout easily crushed its competition, Christopher Robin.
As for Christopher Robin, the box office performance very much matches the critical reaction: it's fine.
While many believe that the censors are behind Christoper Robin's banning, other industry professionals claim that it more to do with the size and scope of the film and the massive number of studio tentpole pictures flooding the market. The next closest studio is Universal, with 14 percent.
Estimated ticket sales for Friday through Sunday at USA and Canadian theaters, according to comScore. If nothing else, the film raised the profile of the 92-year-old Pooh, who still generates more than $1 billion in merchandise sales annually for Disney.
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Also arriving in wide release was a lightly marketed, poorly reviewed science-fiction thriller called "The Darkest Minds", which cost 20th Century Fox roughly $34 million to make and sold $5.8 million in tickets.
Landing with a thud in third was Lionsgate's action comedy The Spy Who Dumped Me with a lifeless $12.3 million from 3,111 theaters.
Rounding out the top five was the Sony's The Equalizer 2 with $8.8 million from 2,725 screens.
"Incredibles 2", $5 million ($19 million international).
The latest movie adaptation of a young adult book series was trashed by the critics and ignored by public.
Rogue Nation and Fallout writer-director Christopher McQuarrie unraveled the mystery surrounding Jeremy Renner's role on the Empire podcast - "Jeremy had his commitment to Avengers, which ironically they ended up not exercising, and we didn't know what the [sixth Mission: Impossible] movie was, so we couldn't provide a schedule".