Osaka set a personal milestone by securing her first grand slam semifinal, and brought some pride to her home nation by becoming the first Japanese woman to advance to the final four of a slam tournament in two decades.
Here we take a look at the two matches and predict a victor for both. Sevastova ousted defending champion Sloane Stephens in the quarterfinals and has never faced Williams.
Serena Williams wants to win one for the mothers.
As Osaka has climbed the ranks in women's tennis, her identity has been the subject of curiosity for many tennis fans.
It means Nishikori reaches a Grand Slam semi-final for the third time in his career.
Osaka had it much easier, continuing what's been a largely dominant run through the draw by winning in just 57 minutes, the third time in her five matches she didn't even have to play an hour.
Madison Keys of the US celebrates match point against Carla Suarez Navarro of Spain in a quarterfinal match on day ten of the 2018 U.S. Open tennis tournament at USTA Billie Jean King National Tennis Center. They've both played commanding tennis from the baseline this year, relying on similar tools.
"I really, really, really hope she makes it to the final here and I hope that we do, too". It's not every day you play semi-finals of a Grand Slam'.
Osaka, the daughter of a Japanese mother and Haitian father, said she enjoyed playing in the blistering heat of NY which has been such a talking point of the tournament.
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"I don't really feel pressure from them", Osaka said. She clearly knows mine. She will step in and powder the ball, pushing Sevastova back and making it hard for her to bring her finesse into play.
The first meeting between these two young big-hitters came two years ago on Arthur Ashe Stadium.
"It's good news to encourage the Japanese people right now", said journalist Hidehiro Akiyama, one of more than a dozen writers and broadcasters from Japan covering the tournament.
The amount of sand or other granular items in the surface's top layer can be adjusted to make a court faster, which is what's responsible for the change, according to Brewer, rather than the recent switch from asphalt to cement underneath each court at Flushing Meadows.
Keys began her US Open campaign with a confident 6-4 6-4 win over Pauline Parmentier before dismissing her compatriot Bernarda Pera 6-4 6-1.
She has made it to the final four at three of the past five Grand Slam tournaments but is still seeking her first major championship.
Keys will face Japan's Naomi Osaka, the No. 20 seed, in the semifinal.
Suarez Navarro, whose own service game was under pressure, told reporters the 14th-seeded American had simply outplayed her. "I know that I'm fast when I want to be". "She looks older, but when we talk, she's also a kid".