Guardiola lost a midfielder of his own in midweek, with Ilkay Gundogan limping out of the Champions League win at Hoffenheim with a hamstring injury.
Defeat to City at Anfield would spark concerns that the Reds are still not ready to win a first league title since 1990 - but Klopp can be confident.
The Premier League's top two sides face-off on Merseyside in what is sure to be a mouth-watering clash between title contenders.
Liverpool ended City's unbeaten run in the top flight in January, when they won a thrilling game 4-3 at Anfield, and they also knocked Pep Guardiola's side out of the Champions League quarter-finals with a 5-1 aggregate triumph.
The Reds haven't lost to Manchester City in the Premier League at Anfield since former Liverpool FC striker Nicolas Anelka came back to haunt his ex-manager Gerard Houllier's decision not to sign the France worldwide on a permanent deal.
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La joven logró escapar en noviembre de aquel año, gracias a la ayuda de los vecinos. Acabó en un campo de refugiados de Irak y después se trasladó a Alemania.
"At home we made very good game as well".
City also have a awful record at Anfield having lost 12 of their last 17 visits, with their last away victory in 2003.
Of course, that 1-0 loss was only Liverpool's second of the season, and neither of those reverses have come in the Premier League. It's all good. What's massively changed is only the kind of questions you ask.
"What I know, because I know how I would be in that situation, is that they lost the quarter-finals against us a year ago and the league game here after a long run without a defeat and they want to respond".
Man City striker Sergio Aguero has played nine matches in all competitions at Anfield in his career (seven with Man City, two with Atletico Madrid), failing to score in any of those games, attempting just 11 shots and three on target. We try to be close to them.
The Liverpool manager was never going to admit publicly to any misgivings and, if he were one for statistics, the relevant numbers to support his view that nothing is really wrong would not have been hard to dredge up. In it, Pep Guardiola's thoughts are drifting towards an imminent visit to Anfield when he makes the frank admission that Liverpool's front three "scare me". If we would not entertain the people, why would we play it then?