Several others came forward to accuse Kavanaugh of lewd acts. The confirmation vote was delayed by an FBI investigation into the allegations, which concluded in under a week.
At no time did members of Dr. Ford's team advise Committee staff that she could not travel to Washington, D.C. because of her fear of flying.
"Shame on you", two female protesters shouted at Manchin as he voted yes.
The confirmation will mark a major victory for President Donald Trump, who will soon be able to take credit for appointing two conservative justices to the Supreme Court during his relatively brief time in office so far. Protesters have gathered there too to continue the demonstrations.
In reference to protesters who came out to show opposition to the decision, Trump poked fun by suggesting the number of people didn't compare to his supporters at rallies.
President Trump watched the vote play out from onboard Air Force One as he flew to Kansas.
So what were the numbers in the Senate?
The upper house is split 51-49 in favour of the Republicans and the vote was largely along party lines.
A vote on confirmation could happen as early as Saturday.
The lone Republican to oppose the nomination was Murkowski, who told reporters that while she believes Kavanaugh is "a good man", she also felt the confirmation process had become about something "bigger than a nominee". Steve Daines of Montana, who supports Kavanaugh but was in Montana to walk his daughter down the aisle at her wedding.
Hoy será un sábado lluvioso en el Valle de México
En este contexto, esperamos para este sábado cielo algo a parcialmente nublado, pero con nubosidad en disminución desde la tarde . El SMN ha especificado que allí también el cielo se verá parcialmente nublado.
What was said in the Senate?
"We will be ill-served in the long run if we abandon the presumption of innocence and fairness, tempting though it may be", Collins said in remarks that stretched for more than 40 minutes but addressed the sexual-abuse allegations only near the end.
She then claimed Kavanaugh tried to rip her clothes off and held his hand over her mouth to stop her from screaming.
Senate Majority Leader Mitch McConnell said the actions of Democrats on the Judiciary Committee have tarnished the dignity of the upper chamber.
He added: "Brett Kavanaugh is a man of great character and intellect".
Joe Manchin is facing a hard re-election campaign in West Virginia, a traditionally Republican state that Mr Trump won by a landslide. "However, based on all of the information I have available to me, including the recently completed Federal Bureau of Investigation report, I have found Judge Kavanaugh to be a qualified jurist who will follow the Constitution and determine cases based on the legal findings before him".
"Senator Susan Collins has people more motivated than we've ever seen before", Crowdpac tweeted. Chief Justice John Roberts administered the constitutional oath and retired Supreme Court Justice Anthony Kennedy administered the judicial oath, according to the Supreme Court.
Basically, it's the final arbiter of U.S. law. The protests underscored the vital importance of an appointment that will have sweeping consequences for some of the nation's most contested disputes over abortion, LGBT rights, the scope of presidential power and the role of religion in society. Mr Trump's choice of Neil Gorsuch strengthened the conservative leaning.
The bitter fight over Kavanaugh now moves into the epicenter of the campaign for the midterm elections in November. This media house does not correct any spelling or grammatical error within press releases and commentaries.