It would be a big blow for Mourinho if Matic was ruled out of the game against his former club as the Serbian has been a key player for United once again this season having started in every game he's been available for so far this campaign.
'It is alleged that his language at the end of the fixture, as captured by the broadcast footage, was abusive and/or insulting and/or improper'.
The Portuguese coach was reported to have directed an insult in his native language towards a camera which was live tracking him down the touchline after his side's 3-2 comeback win at Old Trafford.
Mourinho has until 18:00 BST on Friday to respond to the charge.
Diseño deportivo, monitorización física y dos semanas de autonomía — Huawei Watch GT
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His side had been 2-0 down at half-time of the Premier League game, against a winless Newcastle, but they rallied in the final 20 minutes to win with goals from Juan Mata, Anthony Martial and Alexis Sanchez.