It was undoubtedly a landmark performance for Southgate's side, but where does it sit among standout England victories from the past 18 years?
For Spain, though, this was the country's first loss in four games (three of the Nations League), having won each of their last three games on the spin (including the friendly versus Wales). "We pushed them back after [half-time]".
"I have to thank this city, which is great to play in, and they leave you in awe so it is a shame we couldn't respond for them".
The 10 goals accrued against Croatia and Wales were scored by seven different players, with Pickford admitting he will need a good night at the Estadio Benito Villamarin.
¿De Cristal? Vermaelen se volvió a lesionar
Esta mañana viajó a Barcelona y se sometió a una serie de pruebas médicas que determinaron su baja para el próximo mes y medio. Está roto y por tanto queda fuera de los terrenos de juego para seis semanas por su dolencia en el bíceps femoral.
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It was Spain's first loss at home to England since 1987, ending Luis Enrique's undefeated start after his appointment in July. "We had chances to come back".
"We've had some young players to have emerged who have given us some more options and right across the week, the mentality of the players has been outstanding and they should enjoy tonight". We needed to be fearless with the ball.
'It was a attractive feeling; I put a lot of pressure on myself to get in the box and score goals, and sometimes it works for you and sometimes it doesn't but it's my position to score goals and I need to keep that going.
Manchester City forward Raheem Sterling put England in front after just 16 minutes, following a neat combination with Marcus Rashford. We had to get passes out of the Spain press spot on. As tight as the result was, it has sparked social media into a frenzy, with many football fans taking to Twitter to express their views. The quality of the decision making, passing, finishing was top.