While critics of Pence have tried to catch him in a "gotcha!" moment by pointing out that Georgia has a booming film industry, that doesn't negate the fact that Hollywood is the hub of entertainment and a symbol of coastal elitism.
Speaking before the Republican-leaning suburbs of Atlanta, Ms Winfrey urged voters to make history by backing Democratic candidate Stacey Abrams in next week's midterm elections.
He declared that he had "a message for all of Stacey Abrams' liberal Hollywood friends: This ain't Hollywood".
Donald Trump, who plans to appear with Mr Kemp later this week told reporters at the White House: "I've always liked Oprah".
"I'm not here because I'm making some grandstand for myself".
Winfrey has always been rumored to be a 2020 presidential candidate, but she quelled those rumors in her Thursday speech.
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Vice President Mike Pence fired back Thursday at Oprah Winfrey and other "Hollywood liberals" who were campaigning for Stacey Abrams, the Democratic candidate for the gubernatorial race in Georgia. Democrat Stacey Abrams is now running for governor of Georgia, and if elected, she would be the first African-American woman governor ever. "I'm not testing the waters", she said.
More than 1.5 million Georgians already have cast ballots.
Winfrey did not mention Pence or the frequent GOP broadsides about "Hollywood" outsiders.
Videos uploaded to Ms Winfrey's and Ms Abrams' social media showed the television personality knocking on doors canvassing for the hopeful governor. I was just sitting at home in California minding my own business but I could not stop thinking about what's going on down here. He's banking on running up wide margins outside metro Atlanta and holding most of the GOP votes closer to the city.
Winfrey and Abrams greet a crowd gathered for a town hall conversation in Marietta, Ga.