The charges against Sayoc were filed in the Southern District of NY.
The 56-year-old appeared in court wearing a blue T-shirt with his gray hair pulled back in a tight pony tail.
Sayoc is due to return to a federal court on Monday for a preliminary hearing.
He seemed calm throughout the 10-minute hearing.
"Yes sir, 100 percent", he answered Magistrate Judge Robert Lehrburger.
Prosecutors said Sayoc "used mailing materials almost identical to the other 15 packages, including the same type of envelope, address format and stamps" on this package.
Exorbitantes precios en reventa para la Final Boca-River
El uruguayo Lucas Olaza nunca jugó un Boca-River y su estreno será nada menos que en la final . Las finales son trabadas, no son abiertas, es muy difícil encontrar una final de palo y palo.
Prosecutors in NY plan to argue Tuesday that Sayoc should continue to be held without bail pending trial, due to being a flight risk and posing a danger to the public.
Sayoc's lawyer, Sarah Baumgartel, didn't fight the request and may make an application for bail at a later date. Sayoc was charged with the mailing of explosives, threatening a former president, making threatening interstate communications and assaulting federal officers, according to The Independent.
The first bomb discovered was sent to billionaire investor George Soros at his home in New York's Westchester County, and some of the other high-profile targets also live in NY state, including former President Bill Clinton and former Secretary of State Hillary Clinton.
Sayoc faces almost 50 years in prison if convicted. Kamala Harris, D-Calif., former CIA Director John Brennan and former Director of National Intelligence James Clapper.
The Washington Post reported Sunday that Trump is "painting an astonishingly apocalyptic vision of America under Democratic control in the campaign's final days, unleashing a torrent of falsehoods and portraying his political opponents as desiring crime, squalor and poverty".
None of the devices exploded before being intercepted and no one was hurt. Debbie Wasserman Schultz, matching labels found on the packages Sayoc allegedly used to mail the explosive devices.