He was captured by Daesh militants in October 2013 while delivering food and medical supplies to refugees in eastern Syria.
An Islamic State leader tied to the beheading of American aid worker Peter Kassig has been killed in an airstrike, the U.S. military said Monday.
Ryan said the jihadist had also been involved in the execution of several other prisoners.
His parents, Ed and Paula Kassig, had issued numerous appeals for his release after his life was threatened in an October 2014 IS video that showed the beheading of a fellow aid worker, Britain's Alan Henning.
The US-led coalition is supporting Kurdish and Arab militias fighting to oust IS fighters on the border with Iraq.
The US-led coalition's anti-Daesh activities in Syria are authorized neither by the Syrian government, nor by the UN Security Council.
Quoting a military source, it said the bombardment had caused only material damage.
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"The group was lost in the middle of the desert around 35 kilometres from the Al-Tanf base", the Observatory's director Rami Abdel Rahman told AFP.
"The coalition forces carried out specific strikes against a high-ranking ISIS leader, Abou al Oumarayn.in the desert" in Syria, says Sean Ryan, spokesman for an worldwide anti-jihadist coalition.
"False, the strikes were as the report stated and directed at ISIS", he said, using another acronym for the jihadist organisation.
Kassig was also a certified emergency medical technician who provided trauma care to wounded Syrians and helped train more than 100 civilians to provide medical aid.
He was said by his friends to have converted to Islam in captivity and took the first name Abdul-Rahman.
His killing was part of a gruesome series of Western hostage beheadings that Daesh filmed and published to shock the world as it attempted to expand across the region.
IS executioner Mohammed Emwazi - aka "Jihadi John" was believed responsible for the killing, along with the deaths of other Western hostages.
Islamic State has lost almost all the territory it once controlled, spanning Syria and Iraq.